OVERVIEW

OVERVIEW

INFOBAR

The tabs at the top of the screen allow you to access the Introduction, Notebook, Assignments, Glossary, Genetic Calculator, and Help.

VIEW TABS

These tabs show four different views: Information, Full Pedigree, Large Family, and Chromosome View

INFORMATION
This screen give background information on the chosen mutation.


FULL PEDIGREE
Shows the entire pedigree. The full pedigrees incorporate instances of rare diseases. You should look at several different pedigrees to determine a pattern of inheritance. Within the full pedigree screen are

LARGE FAMILY
You can search a "simulated database" of large family pedigrees. Each pedigree shows the parents, grandparents, and offspring of one family. Answer the three questions to help you limit the search results to pedigrees that meet certain criteria. For each pedigree you must decide whether or not you can identify offspring that were produced by recombination of the disease and the selected RFLP probe. You can tally the number of nonrecombinant and recombinant offspring to test if the disease gene is linked to the RFLP probe, and if so, how far apart they are on the chromosome. Within the large family screen are

CHROMOSOME VIEW
This view represents portions of four of the 22 human autosomes and the X-chromosome. Each chromosome segment is 20 map units in length. The telomeres (ends of chromosome) appear as rounded and the centromeres appear as ovals. The chromosome number appears below chromosme segment. The selected genetic disease is located somewhere on this genetic map. You can drag the colored pointer on the right side of the window to your best curtrent estimate for its correct location on one of the chromosomes.